EVALUATION OF PHARMACOGNOSTICPARAMETERS AND HEPATOTOXIC EFFECTS OF EXTRACTSOF CASSYTHA FILIFORMIS LINN ON PARACETAMOL-INDUCED LIVER DISORDERS IN WISTER RATS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 5000
ABSTRACT
Cassytha filiformis, a leafless and perennial vine with small scales as a replacement of the leavesis currently being used in the treatment of various disease conditions including jaundice without standardization.Microscopical evaluation, chromatographic analysis (TLC, HPLC, LC-MS/MS), spectroscopic analyses (NMR, FTIR, MS) and hepathoprotective studies were carried out with the view to scientifically verify the potentials of this plant used in traditional medicine. The results revealed the presence of some diagnostic microscopical features such as paracytic stomata, unicellular covering trichomes with cystoliths, prismatic calcium oxalate crystals and annular xylem vessels. Quantitative physical constants include moisture contents (5.5 %), ash value (17 %), acid insoluble ash value (1 %), total tannins (27.3 %), swelling index (165 %), water, alcohol and oil extractive indices (20.6 %, 13.6 % and 1.6 % respectively). Trace metals detected in C. filiformis such as Fe (165.4279 ppm), Mn (14.4093 ppm) and Ni (2.7933 ppm) which are essential were higher than FAO/WHO (1984) permissible limit for edible plants. While others:Pb (0.0568 ppm) Zn (0.1094 ppm), Cd (0.0103 ppm) and Cu (0.0535 ppm) were found to be within the safety limit. Preliminary phytochemical screening of the plant signifies the presence of alkaloids, tannins, flavonoids, saponins and steroids Phytochemical constituents identified in ethyl acetate and methanol extracts of C. filiformis include 3,3,O-di-O-methyl ellagic acid, catechin, chalcone compounds, phydroxybenzoic acid, isorhamnetin 3-O-rutinoside or isorhamnetin 3-O- viii neohesperidoside, kaemferol 3 rutinoside and 2-{cyclohex-2-en-1- yl(hydroxyl)methyl}-3-hydroxy-4-(2-hydroxyethyl)-3-methyl- oxoprolinate while that of methanol fraction include 3,3,O-di-O-methyl etllagic acid, methy2- {cyclohex-2-ene-1-y(hydroxyl)methyl}-3-hydroxy-4-(2-hydroxyethyl)-3-methyl-5- oxoprolinate, kaemferol 3 rutinoside, rutin and cathechinas revealed by the library search on LC-MS/MS. Other compounds β-sitosterol and stigmasterol wereisolated from petroleum ether extracts.The petroleum ether extract (500 mgkg-1 ) and methanol (500 and 1000 mgkg-1 ) exhibited hepatoprotection properties on wistar albino rats. These results could serve as bases for the use of the plant in traditional medicine for the prevention of liver disorders.
Related Project Materials
An Assessment of Waterborne Disease Outbreaks and Their Control in Benue State
Background of the Study
Waterborne diseases are a major public health issue in many parts of Nigeria,...
MODERN OFFICE EQUIPMENTS AND THEIR CONTRIBUTIONS TO THE SUCCESS OF A BUSINESS ORGANIZATION
ABSTRACT
This study was carried out to examine the modern office equipments and their...
The Effect of Electronic Nursing Documentation on Workload Reduction at Federal Medical Centre, Yola
Background of the Study
Electronic nursing documentation (END) has revolutionized healthcare record-keeping by replacing traditional pape...
The influence of vocational education on reducing dropout rates in secondary schools in Kaduna North Local Government Area, Kaduna State
Background of the Study
High dropout rates in secondary schools have long posed a challenge to educational development in...
An Evaluation of Nurses' Knowledge and Practice in HIV/AIDS Care in Sokoto State Hospitals
Background of the Study: HIV/AIDS remains a major public health challenge worldwide, and Nigeria is one of t...
An investigation of semantic universals in Yoruba language across different dialects in Osun State
Background of the study
Semantic universals refer to concepts or meanings that remain consistent across different linguisti...
An assessment of the impact of online learning on students' writing skills in secondary schools in Bauchi Central LGA, Bauchi State
Background of the Study:
With the rapid expansion of online learning, understanding its impact on specific academic skills...
CAPITAL STRUCTURE IMPACT ON THE PERFORMANCE OF BANKING INDUSTRY IN NIGERIA
Abstract
This study examines the impact of capital structure on the performance of the banking industry in Nigeria. The...
An Appraisal of the Effectiveness of Referral Marketing Strategies: A Case Study of Jumia Nigeria in Adamawa State
Background of the Study
Referral marketing is a strategy that encourages existing customers to refer new customers, leve...
An Appraisal of Oncology Nurses' Role in Improving Treatment Compliance Among Leukemia Patients at Delta State University Teaching Hospital, Delta State
Background of the Study
Leukemia is one of the most common types of cancer affecting both children and adults, with the treatment regimen...
